Characterization of early transcriptomic changes associated with hepatitis B virus exposure in human and macaque immune cell populations
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ABSTRACT: Chronic hepatitis B virus (HBV) infection affects close to 300 million individuals worldwide, representing one of the major etiological factors for the development of cirrhosis and hepatocellular carcinoma (HCC). At the molecular level, the mechanisms behind chronic HBV infection are based on the persistence of the viral genome as an episomal structure termed covalently closed circular DNA (cccDNA), and the evasion of both innate and adaptive immune responses. Thus, it is considered that HBV cure will be a multi-layered combination approach of anti-viral and immune-boosting strategies. Although the development of potential HBV therapeutics has been hampered by the lack of suitable long-term infection models, the stark contrast between human and non-human primates regarding their immune responses and infection outcomes, represents an opportunity to identify the molecular mechanisms favoring HBV elimination. Therefore, we aimed to characterize the early transcriptomic changes associated with HBV exposure in human and macaque immune cell populations.
ORGANISM(S): Macaca fascicularis Homo sapiens
PROVIDER: GSE223073 | GEO | 2023/08/08
REPOSITORIES: GEO
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