Extracellular succinate induces spatially organized biofilm formation in Clostridioides difficile

ABSTRACT: we report that succinate, a metabolite abundantly produced by the dysbiotic gut microbiota, induces in vitro biofilm formation of C. difficile strains. We characterized the morphology and spatial composition of succinate- induced biofilms, and compared to non-induced or deoxycholate-induced biofilms, biofilms induced by succinate are significantly thicker, structurally more complex, and poorer in proteins and exopolysaccharides (EPS).

ORGANISM(S): Clostridioides difficile

PROVIDER: GSE223108 | GEO | 2023/05/24

REPOSITORIES: GEO