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Microglia regulate basal cerebral blood flow and neurovascular coupling through ectonucleotidase CD39

ABSTRACT: Microglia tightly interact with brain capillaries and regulate blood brain barrel permeability in pathological conditions. However, it is still unknown whether and how microglia regulate CBF in homeostatic condition. Here we show microglia directly regulate cerebral blood flow (CBF) and neurovascular coupling. Conditional knockout of microglial CD39 resulted in CBF hyper perfusion, reduced ATP induced CBF increase, impaired neurovascular coupling by whisker stimulation and reduced whisker stimulation induced adenosine increase in barrel cortex. Out data suggest that microglia is an important player for CBF regulation.

ORGANISM(S): Mus musculus

PROVIDER: GSE223314 | GEO | 2023/07/01

REPOSITORIES: GEO

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