Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-sequencing of PD-1+ CD8 T cells following two week PD-1 blockade (stem-like and terminally-differentiated subsets).

ABSTRACT: The goal of this study is to characterize the transcriptional profile of PD-1+ stem-like (Tim-3-CD73+) versus terminally-differentiated (Tim-3+CD73-) CD8 T cells following two week αPD-1 blockade.

ORGANISM(S): Mus musculus

PROVIDER: GSE223399 | GEO | 2023/07/17

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

RNA-sequencing of PD-1+ CD8 T cells following two week PD-1 blockade (stem-like and terminally-differentiated subsets).

Project description:RNA-sequencing of PD-1+ CD8 T cells following two week PD-1 blockade (stem-like and terminally-differentiated subsets).

| PRJNA925927 | ENA

Terminally differentiated CD4+ T cells promote myocardial inflammaging

Project description:We generated a xenograft transplantation model in which young humanized mice were treated to harbor a senescent-like human CD4+ T cell compartment. Our data uncover a role for terminally differentiated T cells in promoting cardiac inflammaging.

2021-02-15 | GSE163413 | GEO

Terminally differentiated CD4+ T cells promote myocardial inflammaging

Project description:Terminally differentiated CD4+ T cells promote myocardial inflammaging

| PRJNA686065 | ENA

Anti-PD-1 re-navigates concealed IL-15 to rejuvenate tumor-specific PD-1+CD8+T cells inside the tumor microenvironment

Project description:The authors engineer an anti-PD-1-concealed sIL-15 fusion protein (αPD-1-IL-15-R), eliciting extraordinary antitumor immunity with negligible toxicity. αPD-1-IL-15-R largely expands tumor-specific CD8+T for effective tumor rejection through cis-delivery and further controls metastasis.

2022-09-21 | GSE212545 | GEO

Limited oxygen availability in standard cell culture alters metabolism and function in terminally differentiated cells

Project description:<p>Cell culture is generally considered to be hyperoxic. However, the importance of cellular oxygen consumption is often underappreciated, with rates of oxygen consumption often sufficient to cause hypoxia at cell monolayers. We initially focused on cultured adipocytes as a terminally differentiated cell-type with substantial oxygen consumption rates to support diverse cellular functions. Under standard conditions, cultured adipocytes are hypoxic and highly glycolytic. Increasing oxygen diverted glucose flux toward mitochondria and resulted in thousands of gene expression changes that pointed toward alleviated physiological transcriptional responses to hypoxia. Phenotypically, providing more oxygen increased adipokine secretion and rendered adipocytes more sensitive to insulin and lipolytic stimuli. The functional benefits of increasing pericellular oxygen were transferable to other cellular systems including hPSC-derived hepatocytes and cardiac organoids. Our findings suggest that oxygen is limiting in many terminally-differentiated cell culture systems, and that controlling oxygen availability can improve the quality and translatability of cell models.</p>

2024-02-21 | MTBLS6677 | MetaboLights

10X single-cell RNASeq profiling of tumor-infiltrating CD8+ T-cells from B16-OVA mouse melanoma tumors

Project description:Distinct populations of progenitor exhausted (Tcf1+Tim-3-) and terminally exhausted (Tcf1-Tim-3+) CD8+ T-cells occur in B16-OVA tumors

2018-11-20 | GSE122675 | GEO

Gene expression induced by TSA in undifferentiated human primary myoblasts versus terminally differentiated human myotubes

Project description:Gene expression analysis in human skeletal myoblasts (undifferentiated mononucleated cells, cultured in growth medium - 15% FBS) and human skeletal myotubes (pre-formed myotubes, cultured in differentiation medium – 2% horse serum) exposed to the HDACi TSA (50nM) for 24 hours TSA treated undifferentiated human primary myoblasts and terminally differentiated human myotubes

2011-03-01 | E-GEOD-27073 | biostudies-arrayexpress

Immunotherapy study of phagocytosis checkpoint blockade in combination with radiotherapy

Project description:Transcriptional profiling of tumor-infiltrating antigen-presenting myeloid subsets and CD8 T cells in mice bearing MC38-OVA tumors treated with or without radiotherapy, αSIRPα, and/or αPD-1 treatment

2022-04-19 | GSE197767 | GEO

All-iPS cell mice generated from terminally differentiated B cells

Project description:The generation of induced pluripotent stem cells (iPSCs) often results in aberrant silencing of the imprinted Dlk1-Dio3 gene cluster, which compromises their ability to generate entirely iPSC-derived mice (“all-iPSC mice”). Here, we show that reprogramming in the presence of ascorbic acid attenuates hypermethylation of Dlk1-Dio3 by enabling a chromatin configuration at its imprint control region that interferes with abnormal binding of the DNA methyltransferase Dnmt3a. This approach allowed us to generate adult all-iPSC mice from mature B cells, which have thus far failed to support the development of exclusively iPSC-derived postnatal mice. Our data demonstrate that factor-mediated reprogramming can endow a defined, terminally differentiated cell type with a developmental potential equivalent to that of embryonic stem cells. More generally, these findings indicate that the choice of culture conditions used for transcription factor-mediated reprogramming can strongly influence the epigenetic and biological properties of resultant iPSCs.

2012-02-01 | GSE34761 | GEO

TIM-3 + CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies

Project description:TIM-3 + CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies

| PRJNA1091196 | ENA