Transcriptomics

Dataset Information

0

Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models


ABSTRACT: Intranasal vaccines can prime or recruit to the respiratory epithelium mucosal immune cells capable of preventing transmission of SARS-CoV-2. We found that a single intranasal dose of serotype 5-based adenoviral vectors expressing either the receptor binding domain (Ad5-RBD) or the complete ectodomain (Ad5-S) of the SARS-CoV-2 spike protein was effective in inducing i) secretory and serum anti-spike IgA and IgG, ii) robust SARS-CoV-2-neutralizing activity in the serum and in respiratory secretions, iii) rigorous spike-directed T helper 1 cell/cytotoxic T cell immunity, and iv) protection of wild-type mice from a challenge with the SARS-CoV-2 beta variant. Our data confirm and extend previous studies reporting promising preclinical results on vector-based intranasal SARS-CoV-2 vaccination, and support the potential of this approach to elicit mucosal immunity for preventing reinfection and transmission of SARS-CoV-2 more effectively than the currently available vaccines.

ORGANISM(S): Mus musculus

PROVIDER: GSE223476 | GEO | 2023/05/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-05-04 | GSE193288 | GEO
2024-02-14 | GSE245040 | GEO
2021-08-04 | GSE177027 | GEO
2011-08-31 | E-GEOD-23955 | biostudies-arrayexpress
2021-08-11 | GSE173567 | GEO
2023-05-28 | GSE228112 | GEO
2022-04-04 | GSE199922 | GEO
2023-05-28 | GSE227648 | GEO
2023-05-28 | GSE228111 | GEO
2023-05-28 | GSE227647 | GEO