Long non coding RNA (lncRNA) profiling of the colon epithelium of chronicallly SIV infected Rhesus macaques(RMs) administered either Δ9 THC or Vehicle (VEH)
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ABSTRACT: Here, we describe new information on changes in the lncRNA landscape and their potential role in the pathogenesis of HIV/SIV induced intestinal epithelial dysfunction. Our study provides relevant novel insights on the protective role of the natural anti-sense lncRNA MMP25-AS1 in the colonic epithelium (CE) and its modulation by long-term controlled delta-9-tetrahydrocannabinol (THC) administration during chronic HIV/SIV infection. More specifically, we demonstrate a novel epigenetic mechanism in maintaining intestinal homeostasis by MMP25-AS1 upregulated by THC in CE via direct counteraction of matrix metalloproteinase 25 (MMP25) expression.
ORGANISM(S): Homo sapiens Macaca mulatta
PROVIDER: GSE223482 | GEO | 2023/02/28
REPOSITORIES: GEO
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