Genomics

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Identification of common lupus-disease related microRNA expression pattern in three different murine models of lupus


ABSTRACT: In this study, miRNA expression in splenic lymphocytes from three genetically disparate lupus-prone mouse models (MRL-lpr, B6-lpr and NZB/WF1) were profiled. 49 miRNAs were found to be differentially expressed in MRL-lpr mice compared to MRL mice; and 24 miRNAs were differentially expressed in B6-lpr mice compared to B6 mice. Among these dysregulated miRNAs, we noted that 15 miRNAs were common to both lpr strains. Interestingly, microarray analysis of NZB/W and NZW at 3 months of age, an age when overt lupus disease is not evident in NZB/W mice, revealed that only one miRNA, miR-148a was significantly upregulated in NZB/W mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE22359 | GEO | 2011/12/17

SECONDARY ACCESSION(S): PRJNA127669

REPOSITORIES: GEO

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