Genomics

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Decoding changes in chromatin accessibility mediated by KDM6 histone demethylases [ATAC-seq]


ABSTRACT: To interrogate the function of KDM6A and KDM6B in regulating genome accessibility, we generated U937 cell lines having knockdown of either KDM6A, KDM6B or both using lentiviral shRNA. We then profiled chromatin accessibility changes using ATAC-seq data obtained from the 3 knockdown cell lines compared with the wild type cell line.

ORGANISM(S): Homo sapiens

PROVIDER: GSE223608 | GEO | 2023/01/29

REPOSITORIES: GEO

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