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Constitutive expression and distinct properties of IFN-epsilon protect the female reproductive tract from Zika virus infection.

ABSTRACT: The female reproductive tract (FRT) is vulnerable to sexually transmitted infections and therefore a well-tuned immune surveillance system is crucial for maintaining a healthy FRT. However, our understanding of the factors that impact viral infection of the FRT and the host response are not well understood. In this work, we investigate the role of a hormonally regulated type I interferon, IFN epsilon, in control of Zika virus (ZIKV) infection of the FRT. We demonstrate that IFN epsilon has anti-ZIKV properties using a combination of IFN epsilon KO mice, blockade of endogenous IFN epsilon by neutralising Abs and rescue of IFN epsilon KO mice by recombinant IFN epsilon administered directly to the FRT.

ORGANISM(S): Homo sapiens

PROVIDER: GSE223635 | GEO | 2023/02/14

REPOSITORIES: GEO

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Interferon e restricts Zika infection at the female reproductive tract

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