Genomics

Dataset Information

0

CAMP/PKA signaling promotes AKT deactivation via reducing CIP2A expression, thereby facilitating decidualization


ABSTRACT: Decidualization is a progesterone-initiated differentiation concerning the endometrium and is dedicated to supporting the placenta and embryo development. During the process, cAMP signaling is widely known to be indispensable, but the details are not fully understood. In this study, we show that cAMP signaling promotes AKT deactivation in endometrial stromal cells, which favors their decidualization. The deactivation of AKT is found to be a consequence of the reduced expression of several inhibitors of PP2A, the major phosphatase of AKT, with CIP2A being the most prominent. To show that CIP2A loss is obligatory for decidualization, we performed this ATAC-seq analysis. Persistent CIP2A expression impairs the chromatin accesibility remodeling during decidualization.

ORGANISM(S): Homo sapiens

PROVIDER: GSE224212 | GEO | 2023/02/06

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-02-02 | GSE195984 | GEO
2021-04-27 | GSE173302 | GEO
2021-04-28 | GSE173405 | GEO
2019-08-13 | GSE118094 | GEO
2020-05-26 | PXD010612 | Pride
2021-09-08 | PXD008983 | Pride
2023-03-11 | PXD030297 | Pride
2009-12-19 | GSE17504 | GEO
2003-04-14 | GSE403 | GEO
2021-06-21 | PXD026243 | Pride