Merlin rescue drives Wnt signalling
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ABSTRACT: To investigate the effect of Merlin rescue on cell proliferation in 3D, we grew subcutaneous xenografts from NF2-deficient CH-157MN meningioma cells harboring doxycycline inducible WT-Merlin. Mice were treated with or without doxycycline and Merlin induction was confirmed 24 hours after induction with Western blot. We performed single-cell RNA sequencing on five Merlin-deficient tumors and seven Merlin rescue tumors
ORGANISM(S): Mus musculus Homo sapiens
PROVIDER: GSE224347 | GEO | 2023/08/07
REPOSITORIES: GEO
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