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Single cell ATAC-seq analysis of human dermal fibroblasts and human pluripotent stem cells

ABSTRACT: Human pluripotent stem cells have two major pluripotent states, primed and naive, and the heterogeneity among cell lines in each pluripotent state remains a major unresolved problem. We showed that the overexpression of H1FOO-DD, which has a short expression period by fusing the destabilized domain to the maternal-specific linker histone H1FOO, together with OCT4, SOX2, KLF4 and LMYC in human somatic cells improves the quality of reprogramming to primed and naive pluripotency.

ORGANISM(S): Homo sapiens

PROVIDER: GSE224699 | GEO | 2024/05/01

REPOSITORIES: GEO

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