Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA sequestration in P-bodies sustains myeloid leukemia [ATAC-seq]

ABSTRACT: We performed ATAC-seq to profilechromatin changes in AML cells following P-body dissolution induced by DDX6 knockdown.

ORGANISM(S): Homo sapiens

PROVIDER: GSE224746 | GEO | 2024/07/12

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

RNA sequestration in P-bodies sustains myeloid leukemia [RNA-seq]

Project description:We performed RNA-seq to profile transcriptional changes in AML cells following P-body dissolution induced by DDX6 knockdown.

2024-07-12 | GSE224748 | GEO

RNA sequestration in P-bodies sustains myeloid leukemia [small RNA-seq]

Project description:To investigate small non-coding RNA changes in AML cells following loss of P-bodies, we knocked down DDX6 in MOLM-13 cells.

2024-07-12 | GSE224851 | GEO

The interplay between RNA sequestration in P-bodies and chromatin architecture sustains myeloid leukemia

Project description:To investigate chromatin remodeling in AML cells following loss of P-bodies, we knocked down DDX6 in MOLM-13 cells.

2024-08-09 | GSE224931 | GEO

RNA sequestration in P-bodies sustains myeloid leukemia [HSPC_RNAseq]

Project description:We performed RNA-seq to profile transcriptional changes in hematopoietic stem and progenitor cells following Ddx6 deletion.

2024-08-15 | GSE274860 | GEO

The interplay between RNA sequestration in P-bodies and chromatin architecture sustains myeloid leukemia [CUT&RUN]

Project description:To investigate chromatin remodeling in AML cells following loss of P-bodies, we knocked down DDX6 in MOLM-13 cells.

2024-08-11 | GSE261265 | GEO

RNA sequestration in P-bodies sustains myeloid leukaemia

Project description:Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and are often dysregulated in cancer. Here, we identified regulators of P-bodies as crucial vulnerabilities in acute myeloid leukaemia (AML) through genome-wide CRISPR screens in normal and malignant haematopoietic progenitors. We found that leukaemia cells harbour aberrantly elevated numbers of P-bodies and show that P-body assembly is crucial for initiation and maintenance of AML. Notably, P-body loss had little effect upon homoeostatic haematopoiesis but impacted regenerative haematopoiesis. Molecular characterization of P-bodies purified from human AML cells unveiled their critical role in sequestering messenger RNAs encoding potent tumour suppressors from the translational machinery. P-body dissolution promoted translation of these mRNAs, which in turn rewired gene expression and chromatin architecture in leukaemia cells. Collectively, our findings highlight the contrasting and unique roles of RNA sequestration in P-bodies during tissue homoeostasis and oncogenesis. These insights open potential avenues for understanding myeloid leukaemia and potential therapeutic interventions.

2024-08-08 | GSE260919 | GEO

RNA sequestration in P-bodies sustains myeloid leukaemia

2024-08-08 | GSE224643 | GEO

RNA sequestration in P-bodies sustains myeloid leukemia [P-body-seq]

Project description:We performed RNA-seq to profile transcripts sequestered in P-bodies of AML cells

2024-07-12 | GSE224752 | GEO

RNA sequestration in P-bodies sustains myeloid leukemia

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-07-12 | GSE224858 | GEO

Inhibitors of LSD1 target demethylase-independent activity to induce differentiation in acute myeloid leukemia [ATAC-Seq]

Project description:To identify regions of genome accessibility influenced by LSD1 inhibition, THP1 AML cells were subjected to ATAC sequencing.

2018-03-27 | GSE90770 | GEO