Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Acetate controls endothelial-to-mesenchymal transition during atherosclerosis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE224940 | GEO | 2023/05/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Acetate controls endothelial-to-mesenchymal transition during atherosclerosis [2]

Project description:To investigate the gene expression profiling during endothelial-to-mesenchymal transition , and identify the main changes in metaboltic and EndoMT related genes.

2023-05-01 | GSE224939 | GEO

Acetate controls endothelial-to-mesenchymal transition during atherosclerosis [1]

Project description:To investigate the gene expression profiling during endothelial-to-mesenchymal transition , and identify the main changes in metaboltic and EndoMT related genes.

2023-05-01 | GSE224907 | GEO

The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-01-08 | GSE143151 | GEO

Epigenomic reprogramming during epithelial to mesenchymal transition

Project description:This SuperSeries is composed of the SubSeries listed below.

2011-07-03 | GSE28581 | GEO

Endothelial-to-mesenchymal transition drives atherosclerosis progression.

Project description:The molecular mechanisms responsible for the development and progression of atherosclerotic lesions have not been fully established. Here, we investigated the role played by endothelial-to-mesenchymal transition (EndMT) and its key regulator FGF receptor 1 (FGFR1) in atherosclerosis. In cultured human endothelial cells, both inflammatory cytokines and oscillatory shear stress reduced endothelial FGFR1 expression and activated TGF-? signaling. We further explored the link between disrupted FGF endothelial signaling and progression of atherosclerosis by introducing endothelial-specific deletion of FGF receptor substrate 2 ? (Frs2a) in atherosclerotic (Apoe(-/-)) mice. When placed on a high-fat diet, these double-knockout mice developed atherosclerosis at a much earlier time point compared with that their Apoe(-/-) counterparts, eventually demonstrating an 84% increase in total plaque burden. Moreover, these animals exhibited extensive development of EndMT, deposition of fibronectin, and increased neointima formation. Additionally, we conducted a molecular and morphometric examination of left main coronary arteries from 43 patients with various levels of coronary disease to assess the clinical relevance of these findings. The extent of coronary atherosclerosis in this patient set strongly correlated with loss of endothelial FGFR1 expression, activation of endothelial TGF-? signaling, and the extent of EndMT. These data demonstrate a link between loss of protective endothelial FGFR signaling, development of EndMT, and progression of atherosclerosis.

| S-EPMC4665771 | biostudies-literature

TGF-β regulated RNA-binding proteins control endothelial function and mesenchymal transition in cardiac endothelial cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-10-01 | GSE216228 | GEO

Analysis of Gene Expression changes in human intestinal endothelial-to-mesenchymal transition

Project description:This SuperSeries is composed of the SubSeries listed below.

2011-11-02 | GSE15975 | GEO

TET1 regulates hypoxia-induced epithelial-mesenchymal transition through DNA demethylation

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-08-01 | E-GEOD-59990 | biostudies-arrayexpress

Architecture of Epigenetic Reprogramming Following Twist1 Mediated Epithelial-Mesenchymal Transition

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-12-10 | E-GEOD-53026 | biostudies-arrayexpress

Determination of a comprehensive alternative splicing regulatory network and the combinatorial regulation by key factors during Epithelial-to-Mesenchymal Transition

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-04-05 | E-GEOD-75492 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data