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Effect of SOCS2 R96C mutation on mouse mammary gland development and function

ABSTRACT: The R96C mutation in SOCS2 (suppressor of cytokine signaling 2) that leads to greater milk production but also a greater sensitivity to mastitis was identified in Lacaune sheep by Rupp et al, 2015. This mutation leads to a loss of ligand recognition for SOCS2 and thus interferes with JAK/STAT signaling pathway regulation. A mouse model carrying this mutation (SOCS2 R96C KI) was developed to study its effects on mammary gland development and lactation.

ORGANISM(S): Mus musculus

PROVIDER: GSE225441 | GEO | 2024/02/26

REPOSITORIES: GEO

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Affect of Socs2 loss-of-function on liver regeneration

2014-02-01 | GSE51801 | GEO

Affect of Socs2 loss-of-function on liver regeneration

Project description:SOCS2 Ensures Metabolic Function and Mass Restoration During Liver Regeneration - SOCS2 plays distinct and contrasting roles during liver regeneration. Early after injury, SOCS2 expression increases and limits the rate of regeneration, preserving metabolic activity. Surprisingly, at later times, the role of SOCS2 reverses to promote liver regeneration by stimulating GH release from the pituitary via effects on serum levels of insulin-like growth factor 1. Loss of SOCS2 promotes GH signaling by increasing growth hormone receptor levels and driving phosphorylation of proteins in the GH pathway, establishing a state of hyper-responsiveness to GH. These findings suggest a single protein can play contrasting roles at different times after liver injury and modulation of GH signaling achieves an optimal rate of liver regeneration to balance metabolic and restorative needs. To further understand the mechanism by which SOCS2 increases early liver regeneration, we performed microarray analysis of Socs2-null mice wildtype mice at 24 and 36 hours after hepatectomy. C57BL/6 mice where used as wildtype controls. Socs2-null animals were maintained on a C57BL/6 background. Both wildtype and Socs2-null adult mice were subjected to 2/3 hepatectomy and liver tissue isolated at 24 hours and 36 hours post hepatectomy. Time zero was without hepatectomy in age-matched mice for each genotype. Total RNA isolated from collected liver tissues was pooled for three animals at each time point and two biological replicates (3 pooled liver RNAs each) were labeled for array analysis. This results in a total of 12 microarrays.

2014-02-01 | E-GEOD-51801 | biostudies-arrayexpress

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SOCS2 expression correlates with tumor malignancy, exerts growth promoting effects and is enhanced by androgens in prostate cancer

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Effects of SOCS2-AS1 inhibition in prostate cancer cells

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2016-08-01 | E-GEOD-82224 | biostudies-arrayexpress

Effect of SOCS2 R96C mutation on mouse mammary gland development and function

Project description:Effect of SOCS2 R96C mutation on mouse mammary gland development and function

| PRJNA935704 | ENA

SOCS2 expression correlates with tumor malignancy, exerts growth promoting effects and is enhanced by androgens in prostate cancer

2013-12-03 | E-GEOD-50936 | biostudies-arrayexpress

Effects of SOCS2-AS1 inhibition in prostate cancer cells

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