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The impact of substrate stiffness on morphological, transcriptional and functional aspects in RPE [RNA-Seq]

ABSTRACT: To investigate the influence of stiffness as a major Bruch's membrane characteristic on the RPE transcriptome and morphology. ARPE-19 cells were plated on soft or stiff polyacrylamide gels (PA gels) or standard tissue culture plastic (TCP). We then performed gene expression profiling analysis using data obtained from Next-generation sequencing of small RNAs of ARPE-19 cells cultured on 3 different biomechanical conditions.

ORGANISM(S): Homo sapiens

PROVIDER: GSE225640 | GEO | 2024/03/11

REPOSITORIES: GEO

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| S-EPMC11344127 | biostudies-literature

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