Transcriptomic profiling of 27-year cryopreserved umbilical cord blood HSCs/HPCs
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ABSTRACT: Umbilical cord blood banking is critical for the success of umbilical cord blood transplants. Here we analyzed transcriptomic differences between 27-year cryopreserved umbilical cord blood hematopoietic stem cells (HSCs) and multipotent progenitor cells (MPPs) and those derived from fresh cord blood. We also leveraged differences in engraftment capacity to examine the transcriptomes of HSCs/HPCs defined by engraftment capacity, demonstrating the feasibility of this approach for identifying potency markers to aid in the selection of cord blood units for transplantation and revealing novel potential regulators of cord blood HSC/HPC engraftment.
ORGANISM(S): Homo sapiens
PROVIDER: GSE225699 | GEO | 2023/10/04
REPOSITORIES: GEO
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