Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Adrenalectomy effect on muscle clock.

ABSTRACT: Characterisation the effect of removal of adreanl glands on skeletal muscle rhythmic transcriptome.

ORGANISM(S): Mus musculus

PROVIDER: GSE225764 | GEO | 2024/02/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Sympathectomy effect on muscle clock

Project description:Characterization of the effect of perturbation of sympathetic nervous system (SNS) on skeletal muscle rhythmic transcriptome.

2024-02-01 | GSE225851 | GEO

Adrenalectomy effect on muscle clock.

Project description:Adrenalectomy effect on muscle clock.

| PRJNA937303 | ENA

Sympathectomy effect on muscle clock

Project description:Sympathectomy effect on muscle clock

| PRJNA937717 | ENA

Effect of an Oral Nutritional Supplement on Muscle Mass During Anticancer Treatment

Project description:Malnutrition and low muscle mass (sarcopenia) are common problems in patients with cancer. However, a low muscle mass is associated with negative clinical outcomes in patients with cancer. Therefore, it is very important to maintain muscle mass in this population. This study aims to investigate the effect of an oral nutritional supplement on skeletal muscle mass during anti-cancer treatment.

| 2256 | ecrin-mdr-crc

Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle

Project description:The circadian regulation of transcriptional processes has a broad impact on cell metabolism. Here, we compared the diurnal transcriptome of human skeletal muscle conducted on serial muscle biopsies in vivo with profiles of human skeletal myotubes synchronized in vitro. Extensive rhythmic transcription was observed in human skeletal muscle in comparison to in vitro cell culture. However, nearly half of the in vivo rhythmicity was lost at the mRNA accumulation level. siRNA-mediated clock disruption in primary myotubes significantly affected the expression of ~8% of all genes, with impact on glucose homeostasis and lipid metabolism. Genes involved in GLUT4 expression, translocation and recycling were negatively affected, whereas lipid metabolic genes were altered to promote activation of lipid utilization. Moreover, basal and insulin stimulated glucose uptake were significantly reduced upon CLOCK depletion. Altogether, our findings suggest an essential role for cell-autonomous circadian clocks in coordinating muscle glucose homeostasis and lipid metabolism in humans.

2018-04-16 | GSE108539 | GEO

Genome-wide binding of Bmal1 and Clock in adult mouse skeletal muscle.

Project description:The goal of this study was to define the binding sites of the core circadian factors, BMAL1 and CLOCK across the genome in adult mouse skeletal muscle. We found that mitochondrial inner-membrane genes were among the most enriched rhythmic genes via gene ontology analysis, and ChIP-Seq analysis corroborated the role of Clock and Bmal1 in targeting promoters of mitochondrial inner-membrane genes.

2021-08-12 | GSE143334 | GEO

Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle

Project description:Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle

| PRJNA427586 | ENA

Effect of Sidt2 deficiency on skeletal muscle

Project description:Effect of Sidt2 deficiency on skeletal muscle

| PRJNA450342 | ENA

Effect of constitutive AHR activation in skeletal muscle

Project description:Effect of constitutive AHR activation in skeletal muscle

| PRJNA936613 | ENA

Effect of in utero undernutrition on skeletal muscle gene expression

Project description:In utero undernutrition is associated with obesity and insulin resistance, although its effect on skeletal muscle remains poorly defined. We report that, in mice, adult offspring from undernourished dams have decreased energy expenditure, decreased skeletal muscle mitochondrial content, and altered energetics in isolated mitochondria and permeabilized muscle fibers. Strikingly, when these mice are put on a 40% calorie restricted diet they lose half as much weight as calorie restricted controls. Our results reveal for the first time that in utero undernutrition alters metabolic physiology having a profound effect on skeletal muscle energetics and response to calorie restriction in adulthood.

2014-08-01 | GSE53520 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data