Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

PFG controls gene expression in female gametocytes cooperatively with AP2-FG [AP2-FG_DIP]

ABSTRACT: AP2-FG is a female-specific transcription factor (TF) that plays an essential role in female gametocyte development. AP2-FG activates hundreds of genes by binding to a female-specific ten-base cis-acting element. Here, we report that in the rodent malaria parasite Plasmodium berghei, another female-specific TF designated as a partner of AP2-FG (PFG), controls gene expression in female gametocytes cooperatively with AP2-FG. Transcriptional mechanisms were analyzed in Plasmodium berghei female gametocytes.

ORGANISM(S): Plasmodium berghei

PROVIDER: GSE226020 | GEO | 2024/01/22

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

PFG controls gene expression in female gametocytes cooperatively with AP2-FG [PFG_ChIP-seq]

Project description:AP2-FG is a female-specific transcription factor (TF) that plays an essential role in female gametocyte development. AP2-FG activates hundreds of genes by binding to a female-specific ten-base cis-acting element. Here, we report that in the rodent malaria parasite Plasmodium berghei, another female-specific TF designated as a partner of AP2-FG (PFG), controls gene expression in female gametocytes cooperatively with AP2-FG. Transcriptional mechanisms were analyzed in Plasmodium berghei female gametocytes.

2024-01-22 | GSE226021 | GEO

PFG controls gene expression in female gametocytes cooperatively with AP2-FG [PFG_RNA-seq]

2024-01-22 | GSE226027 | GEO

PFG controls gene expression in female gametocytes cooperatively with AP2-FG [AP2-FG_DIP]

Project description:PFG controls gene expression in female gametocytes cooperatively with AP2-FG [AP2-FG_DIP]

| PRJNA938389 | ENA

PFG controls gene expression in female gametocytes cooperatively with AP2-FG

Project description:PFG controls gene expression in female gametocytes cooperatively with AP2-FG

| PRJNA938380 | ENA

Plasmodium transcription repressor AP2-O3 regulates sex-specific identity of gene expression in female gametocytes [ChIP-seq]

Project description:Male and female gametocytes are sexual precursor cells essential for transmission of malaria parasite in the mosquitoes. Differentiation of gametocytes to fertile gametes (gametogenesis) relies on the gender-specific transcriptome. However, how the parasites establish distinct repertoire of gene transcription in the male and female gametocytes remains largely unknown. Here, we report that an Apetala2 (AP2) family transcription factor (TF) AP2-O3 operates as a transcription repressor regulating female gametocyte transcriptome. AP2-O3 is specifically localized in the nucleus of the female gametocytes. AP2-O3-deficient parasites produce apparently normal female gametocytes, which fail to differentiate to fully fertile female gametes, leading to developmental arrest in fertilization and early development post-fertilization. AP2-O3 disruption causes massive up-regulation of transcriptionally dormant male genes and simultaneously down-regulation of highly transcribed female genes in female gametocytes. ChIP-seq and EMSA analysis establish AP2-O3 as a transcription repressor that targets a significant proportion of the upregulated male genes by recognizing an eight-base DNA motif in the promoters. In addition, the maternal AP2-O3 is removed after fertilization, which is required for the zygote to ookinete development. These results demonstrate that global transcriptional repression of male genes in the female gametocytes is required for safeguarding female-specific transcriptome and essential for the mosquito transmission of Plasmodium.

2021-01-26 | GSE157454 | GEO

Plasmodium transcription repressor AP2-O3 regulates sex-specific identity of gene expression in female gametocytes [RNA-seq]

2021-01-26 | GSE157456 | GEO

Plasmodium berghei transcriptome for female gametocytes, male gametocytes, and asexual erythrocytic stages

Project description:Plasmodium berghei transcriptome for female gametocytes, male gametocytes, and asexual erythrocytic stages

2017-08-21 | GSE102167 | GEO

PFG controls gene expression in female gametocytes cooperatively with AP2-FG [PFG_RNA-seq]

Project description:PFG controls gene expression in female gametocytes cooperatively with AP2-FG [PFG_RNA-seq]

| PRJNA938387 | ENA

PFG controls gene expression in female gametocytes cooperatively with AP2-FG [PFG_ChIP-seq]

Project description:PFG controls gene expression in female gametocytes cooperatively with AP2-FG [PFG_ChIP-seq]

| PRJNA938388 | ENA

Plasmodium berghei WT and ap2-o disruptant ookinete culture 12h

Project description:Plasmodium berghei WT and ap2-o disruptant ookinete culture 12h Plasmodium berghei WT and ap2-o disruptant ookinete culture 12h

2010-05-14 | E-GEOD-14376 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data