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Age-related gene expression signature in limb skeletal muscles and the diaphragm in mice and rats [mouse]

ABSTRACT: As a result of aging, skeletal muscle undergoes atrophy and a decrease in function. This age-related skeletal muscle weakness is known as “sarcopenia.” To understand the changes in gene expression that occur as a result of age in skeletal muscles, we generated a multi-time point gene expression signature throughout the lifespan of mice and rats, as these are the most commonly used species in preclinical research and intervention testing

ORGANISM(S): Mus musculus

PROVIDER: GSE226117 | GEO | 2023/06/19

REPOSITORIES: GEO

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Project description:As a result of aging, skeletal muscle undergoes atrophy and a decrease in function. This age-related skeletal muscle weakness is known as “sarcopenia.” To understand the changes in gene expression that occur as a result of age in skeletal muscles, we generated a multi-time point gene expression signature throughout the lifespan of mice and rats, as these are the most commonly used species in preclinical research and intervention testing

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