Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Muti-Omics Integrated Analysis Reveals Altered metabolism in Sarcopenia.

ABSTRACT: To investigate the metabolic dysfunction in the process of sarcopenia, we collected the skeletal muscles from the participants of healthy aged, pre-sarcopenia and sarcopenia. We then performed gene expression profiling analysis using data obtained from RNA-seq of skeletal muscle tissue from healthy aged, pre-sarccopenia and sarcopenia.

ORGANISM(S): Homo sapiens

PROVIDER: GSE226151 | GEO | 2024/02/22

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Muti-Omics Integrated Analysis Reveals Altered metabolism in Sarcopenia.

Project description:To investigate the metabolic dysfunction in the process of sarcopenia, we collected the skeletal muscles from the participants of healthy aged, pre-sarccopenia and sarcopenia.

2024-08-21 | PXD055032 |

Study of sarcopenia in human muscle biopsies of elderly individuals, Jamaica Sarcopenia Study

Project description:Purpose: The main goal of this study is to compare skeletal muscle transcriptome profilings derived from muscle impaired versus healthy subjects. Methods: We use high coverage RNA sequencing of human skeletal muscle biopsies to analyze genome-wide transcriptional changes in human sarcopenia benchmarked to healthy elderly controls.

2019-11-14 | GSE111010 | GEO

Study of sarcopenia in human muscle biopsies of elderly individuals, Hertfordshire Sarcopenia Study

2019-11-14 | GSE111006 | GEO

Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia

Project description:Molecular mechanisms underlying sarcopenia, the age-related loss of skeletal muscle mass and function, remain unclear. To identify molecular changes that correlated best with sarcopenia and might contribute to its pathogenesis, we determined global gene expression profiles in muscles of rats aged 6, 12, 18, 21, 24, and 27 months. These rats exhibit sarcopenia beginning at 21 months. Correlation of the gene expression versus muscle mass or age changes, and functional annotation analysis identified gene signatures of sarcopenia distinct from gene signatures of aging. Specifically, mitochondrial energy metabolism (e.g., tricarboxylic acid cycle and oxidative phosphorylation) pathway genes were the most downregulated and most significantly correlated with sarcopenia. Also, perturbed were genes/pathways associated with neuromuscular junction patency (providing molecular evidence of sarcopenia-related functional denervation and neuromuscular junction remodeling), protein degradation, and inflammation. Proteomic analysis of samples at 6, 18, and 27 months confirmed the depletion of mitochondrial energy metabolism proteins and neuromuscular junction proteins. Together, these findings suggest that therapeutic approaches that simultaneously stimulate mitochondrogenesis and reduce muscle proteolysis and inflammation have potential for treating sarcopenia.

2018-08-21 | GSE118825 | GEO

Study of sarcopenia in human muscle biopsies of elderly individuals, Singapore Sarcopenia Study

Project description:Purpose: The main goal of this study is to compare skeletal muscle transcriptome profilings derived from sarcopenic versus healthy subjects. Methods: We use high coverage RNA sequencing of human skeletal muscle biopsies to analyze genome-wide transcriptional changes in human sarcopenia benchmarked to healthy elderly controls. Results: Muscle transcriptomic profiles demonstrate a prominent signature of mitochondrial dysfunction in sarcopenic patients. Conclusions: Our study supports the fundamental role of mitochondrial dysfunction in driving pathological muscle and mobility decline in the elderly.

2019-11-14 | GSE111016 | GEO

Novel Sarcopenia-related Alterations in Sarcomeric Protein Post-translational Modifications in Skeletal Muscles Identified by Top-down Proteomics

Project description:Sarcopenia, the age-related loss of skeletal muscle mass and strength, is a significant cause of morbidity in the elderly and is a major burden on health care systems. Unfortunately, the underlying molecular mechanisms in sarcopenia remain poorly understood. Herein, we utilized top-down proteomics to elucidate sarcopenia-related changes in the fast- and slow-twitch skeletal muscles of aging rats with a focus on the sarcomeric proteome, which includes both myofilament and Z-disc proteins--the proteins that constitute the contractile apparatuses.

2017-06-12 | MSV000081157 | MassIVE

RNA-seq from gastrocnemius muscles from rats aged 6, 12, 18, 21, 24 and 27 months

Project description:To gain new insights into molecular changes in skeletal muscle aging and disease with a special focus on differential alternative splicing and senescence, we performed RNA-seq on rat gastrocnemius muscles of animals aged 6, 12, 18, 21, 24 and 27 months, using a rat sarcopenia model we had previously established.

2021-06-26 | E-MTAB-10583 | biostudies-arrayexpress

Profiling muscle from aged rat model for sarcopenia

Project description:This program aims at identifying a muscle gene signature associated with aging in rat sarcopenia model The profiling data was analyzed by identifying genes that were up- and down-regulated at selected p value and fold change in the muscle of aged rats compared to the young controls.

2013-03-22 | E-GEOD-38077 | biostudies-arrayexpress

Muti-Omics Integrated Analysis Reveals Altered metabolism in Sarcopenia.

Project description:Muti-Omics Integrated Analysis Reveals Altered metabolism in Sarcopenia.

| PRJNA939093 | ENA

Metabolomic analysis of skeletal muscle in young and aged mice

Project description:Sarcopenia is the age-induced, progressive loss of skeletal muscle mass and function, which results in poor muscle performance. To better understand changes in skeletal muscles during sarcopenia, we performed a metabolomic analysis of skeletal muscle in young (8-week-old) and aged (28-month-old) mice using CE-TOFMS. Our data shows that the metabolites including glucose and polyamine metabolism were decreased in aged mice compared with young mice. In addition, neurotransmitter levels were higher in aged mice.

2019-05-06 | ST001179 | MetabolomicsWorkbench

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data