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Microarray expression analysis depicting MHCII-dependent features of FOXP3-expressing CD4 T regulatory cells

ABSTRACT: Analysis comparing K14 and MCHII+/- Tregs. The hypothesis was that the lack of MHCII+/- in the spleen and intestine would result in a large shift in K14 Treg gene expression away from an activated and effector phenotype. Results demonstrate how a lack of MHCII-antigen presentation in the small intestine, where Tregs exhibit an effector penotype, does not greatly reduce effector features of T regulatory cells in K14 mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE226193 | GEO | 2023/11/15

REPOSITORIES: GEO

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