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Epigenetic Switch Reshapes Epithelial Stem/Progenitor Cells Signatures and Contributes to Inflammatory Programming in Hidradenitis Suppurativa [CUT&RUN]

ABSTRACT: 1) By using dual-omics profiling for both chromatin accessibility and gene expression as well as CUT&RUN sequencing for chromatin modification states, we identified that numerous disease-associated inflammatory enhancers were epigenetically activated and co-exist with the transcriptional states of their target genes in basal progenitor cells. 2) By using CUT&RUN sequencing , we identified numerous S100A8 binding DNA sequences in HS epidermal cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE226425 | GEO | 2023/10/18

REPOSITORIES: GEO

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