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P53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation driven pancreatic cancer

ABSTRACT: To investigate the transcriptomic effects of iASPP deletion or p53 mutation in the KRASG12D background Pdx1-Cre was used to delete iASPP in oncogenic KRASG12D expressing (KC) background to generate KC;iASPPΔ8/Δ8 mice. KC and KC;iASPPΔ8/Δ8 mice were then crossed with mice containing a p53R172H allele (equivalent to human p53 hotspot mutation R175H) to generate KPC and KPC;iASPPΔ8/Δ8 cohorts. Primary cell cultures were then derived from pancreatic ductal adenocarcinoma tissue for RNA-seq.

ORGANISM(S): Mus musculus

PROVIDER: GSE226595 | GEO | 2023/07/06

REPOSITORIES: GEO

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Selective and direct p53 inhibition by iASPP

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Selective and direct p53 inhibition by iASPP

Project description:Selective and direct p53 inhibition by iASPP

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