Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression changes of ecDNA in colorectal epithelium-adenoma-adenocarcinoma evolution (mRNA)

ABSTRACT: We collected 5 normal colon tissues, 5 colorectal adenomas, and 5 colorectal cancer tissues for high-throughput sequencing. Identify differential expression changes in mRNA during disease progression

ORGANISM(S): Homo sapiens

PROVIDER: GSE226739 | GEO | 2024/11/27

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Expression changes of ecDNA in colorectal epithelium-adenoma-adenocarcinoma evolution (eccDNA)

Project description:We collected 5 normal colon tissues, 5 colorectal adenomas, and 5 colorectal cancer tissues for high-throughput sequencing， Identify differential expression changes in ecDNA during disease progression

2024-11-27 | GSE226738 | GEO

Expression changes of ecDNA in colorectal epithelium-adenoma-adenocarcinoma evolution

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-11-27 | GSE226741 | GEO

Expression changes of ecDNA in colorectal epithelium-adenoma-adenocarcinoma evolution

Project description:Expression changes of ecDNA in colorectal epithelium-adenoma-adenocarcinoma evolution

| PRJNA941306 | ENA

Identification of a gene expression signature in colorectal adenocarcinoma in comparison with colorectal adenoma

Project description:We showed that a lot of genes were deregulated in colorectal adenocarcinomas in comparison with colorectal adenomas. 37 colorectal adenoma and 9 colorectal adenocarcinoma samples were analyzed. We generated a comparison between adenocarcinomas and adenomas.

2013-08-27 | E-GEOD-50115 | biostudies-arrayexpress

Gene expression profiling of colorectal normal mucosa, adenoma and adenocarcinoma tissues

Project description:Approximately two decades ago, Vogelstein and Fearon proposed the adenoma-carcinoma sequence of sporadic CRC development and illustrated the accumulation of genetic alterations during the stepwise progression, thereby providing a guideline for clinical practice. Although the detection and excision of precancerous lesions could prevent colorectal cancer and reduce mortality, 6% of adenomas will ultimately develop into colorectal cancer. Thus, this genetic model for colorectal tumorigenesis may not completely reflect the complex essence of the disease and whether the mode of initiation of the events in the multistep progression affects the outcome of CRC is still unknown. In this study, mRNA and miRNA expression profiling was performed with human colorectal tissues, including normal mucosa, adenoma and adenocarcinoma. Then, an integrated approach was adopted to establish the regulatory interaction networks that were correlated with colorectal carcinogenesis. Finally, a 55-gene signature whose expression was down-regulated in precancerous lesions compared to normal tissue was identified as a potential early indicator of CRC survival. The results suggested that genes related to immunity and homeostasis played a critical role in protection against adenoma initiation and that the altered molecular events that influence colorectal cancer prognosis may be set in an early, precancerous stage. Four types of human colorectal tissues were selected by colonoscopic resection or colorectal surgery, including 12 normal mucosae, 21 low-grade adenomas (mild or moderate atypical hyperplasia), 30 high-grade adenomas (severe atypical hyperplasia or carcinoma in situ) and 25 adenocarcinomas. Gene expression profiling analysis of these samples was performed using Agilent 4x44K human whole genome gene expression microarray (G4112F).

2015-10-16 | E-GEOD-41657 | biostudies-arrayexpress

MicroRNA expression profiling of colorectal normal mucosa, adenoma and adenocarcinoma tissues

Project description:Approximately two decades ago, Vogelstein and Fearon proposed the adenoma-carcinoma sequence of sporadic CRC development and illustrated the accumulation of genetic alterations during the stepwise progression, thereby providing a guideline for clinical practice. Although the detection and excision of precancerous lesions could prevent colorectal cancer and reduce mortality, 6% of adenomas will ultimately develop into colorectal cancer. Thus, this genetic model for colorectal tumorigenesis may not completely reflect the complex essence of the disease and whether the mode of initiation of the events in the multistep progression affects the outcome of CRC is still unknown. In this study, mRNA and miRNA expression profiling was performed with human colorectal tissues, including normal mucosa, adenoma and adenocarcinoma. Then, an integrated approach was adopted to establish the regulatory interaction networks that were correlated with colorectal carcinogenesis. Finally, a 55-gene signature whose expression was down-regulated in precancerous lesions compared to normal tissue was identified as a potential early indicator of CRC survival. The results suggested that genes related to immunity and homeostasis played a critical role in protection against adenoma initiation and that the altered molecular events that influence colorectal cancer prognosis may be set in an early, precancerous stage. Four types of human colorectal tissues were selected by colonoscopic resection or colorectal surgery, including 15 normal mucosae, 39 low-grade adenomas (mild or moderate atypical hyperplasia), 20 high-grade adenomas (severe atypical hyperplasia or carcinoma in situ) and 33 adenocarcinomas. MicroRNA expression profiling analysis of these samples was performed on Agilent 8Ã16K Human miRNA Microarray V3 (G4470C).

2015-10-16 | E-GEOD-41655 | biostudies-arrayexpress

Expression changes of ecDNA in colorectal epithelium-adenoma-adenocarcinoma evolution (eccDNA)

Project description:Expression changes of ecDNA in colorectal epithelium-adenoma-adenocarcinoma evolution (eccDNA)

| PRJNA941311 | ENA

Expression changes of ecDNA in colorectal epithelium-adenoma-adenocarcinoma evolution (mRNA)

Project description:Expression changes of ecDNA in colorectal epithelium-adenoma-adenocarcinoma evolution (mRNA)

| PRJNA941313 | ENA

Identification of a gene expression signature in colorectal adenocarcinoma in comparison with colorectal adenoma

Project description:We showed that a lot of genes were deregulated in colorectal adenocarcinomas in comparison with colorectal adenomas.

2013-08-27 | GSE50115 | GEO

Mapping of RNA Interactomes in Adenoma-carcinoma Sequence of Human Colorectal cancer

Project description:To study the dynamics of RNA interactomes, RIC-seq was performed on several biological replicates of colorectal cancer patients, each including colorectal adenomas, cancerous tissues, and tissues distal to cancer

2023-03-23 | GSE221551 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data