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Copy number profiling of gastric cancer cell lines and gastric tumor tissues

ABSTRACT: Copy number profiling of 27 gastric cancer cell lines and 105 gastric tumor tissues. we hypothesized that a detailed fine-scale survey of genomic CNAs might reveal potential genes disrupted by fusion events in gastric cancer. We inferred the locations of likely chromosomal breakpoints by identifying regions where closely-spaced microarray probes exhibited striking transitions in copy number.

ORGANISM(S): Homo sapiens

PROVIDER: GSE22694 | GEO | 2010/12/31

SECONDARY ACCESSION(S): PRJNA128303

REPOSITORIES: GEO

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Copy number profiling of gastric cancer cell lines and gastric tumor tissues

Project description:Copy number profiling of 27 gastric cancer cell lines and 105 gastric tumor tissues. we hypothesized that a detailed fine-scale survey of genomic CNAs might reveal potential genes disrupted by fusion events in gastric cancer. We inferred the locations of likely chromosomal breakpoints by identifying regions where closely-spaced microarray probes exhibited striking transitions in copy number. 27 gastric cancer cell lines and 105 gastric tumor tissues were profiled by Agilent 244K microarray.

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