Transcriptomics

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IL-21 induces antitumor response in NK cells via CEBPD


ABSTRACT: NK cells engineered to express IL-21 (IL-21 NK) acquire strong antitumor activity, with the ability to respond to glioblastoma (GBM) rechallenge in vitro and in vivo. IL-21 NK cells have a unique signature of chromatin accessibility, with CCAAT/Enhancer-Binding Protein (C/EBP), especially CEBPD, serving as key transcription factors regulating their memory response.

ORGANISM(S): Homo sapiens

PROVIDER: GSE227098 | GEO | 2024/07/09

REPOSITORIES: GEO

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