Effect of repeated optogenetic stimulation on chromatin accessibility in the mouse dentate gyrus [ATAC-seq]
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ABSTRACT: To investigate the effect of repeated neural overactivation in the chromatin accessibility of dentate gyrus neurons, we optogenetically stimulated mouse dentate gyrus repeatedly.
Project description:To investigate the effect of repeated neural overactivation in the transcriptome of dentate gyrus neurons, we optogenetically stimulated mouse dentate gyrus repeatedly.
Project description:The dentate gyrus of the hippocampus is a brain region involved in learning, memory formation, and spatial coding. We performed single-cell RNA-sequencing of the dentate gyrus of young and old mice to identify the age-induced changes.
Project description:In vivo high frequency stimulated of left dentate gyrus was performed on anaesthetised rats followed by RNA-seq to study long-term potentiation. Both left and right dentate gyrus was collected, sequenced and compared against each other for naive rats and for rats 30 min, 2 hours, and 5 hours post-HFS.
Project description:The gene expression patterns in the dentate gyrus of wild-type mice during postnatal development were examined using Affymetrix GeneChip arrays.
Project description:RNA sequencing was performed on 5454 single cells from dentate gyrus of CD-1 mice, sampled at postnatal day 12, 16, 24 and 35, with the aim of studying the postnatal dentate gyrus neurogenesis.