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Rewiring of master transcription factor cistrome during high-grade serous ovarian cancer development [RNA-seq]

ABSTRACT: NOT PROVIDED; REQUESTED

ORGANISM(S): Homo sapiens

PROVIDER: GSE227276 | GEO | 2023/05/12

REPOSITORIES: GEO

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Rewiring of master transcription factor cistrome during high-grade serous ovarian cancer development

Project description:The transcription factors MECOM, PAX8, SOX17 and WT1 are candidate master regulators of high-grade serous ‘ovarian’ cancer (HGSC), yet their cooperative role in the hypothesized tissue of origin, the fallopian tube secretory epithelium (FTSEC) is unknown. We generated 26 epigenome (CUT&TAG, CUT&RUN, ATAC-seq and HiC) data sets and 24 profiles of RNA-seq transcription factor knock-down followed by RNA sequencing in FTSEC and HGSC models to define binding sites and gene sets regulated by these factors in cis and trans. This revealed that MECOM, PAX8, SOX17 and WT1 are lineage-enriched, super-enhancer associated master regulators whose cooperative DNA-binding patterns and target genes are re-wired during tumor development. All four TFs were indispensable for HGSC clonogenicity and survival but only depletion of PAX8 and WT1 impaired FTSEC cell survival. These four TFs were pharmacologically inhibited by transcriptional inhibitors only in HGSCs but not in FTSECs. Collectively, our data highlights that tumor-specific epigenetic remodeling is tightly related to MECOM, PAX8, SOX17 and WT1 activity and these transcription factors are targetable in a tumor-specific manner through transcriptional inhibitors.

2023-05-12 | GSE227779 | GEO

Rewiring of master transcription factor cistrome during high-grade serous ovarian cancer development [Hi-C]

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Rewiring of master transcription factor cistrome during high-grade serous ovarian cancer development

Project description:Rewiring of master transcription factor cistrome during high-grade serous ovarian cancer development

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Rewiring of master transcription factor cistrome during high-grade serous ovarian cancer development [RNA-seq]

Project description:Rewiring of master transcription factor cistrome during high-grade serous ovarian cancer development [RNA-seq]

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Rewiring of master transcription factor cistrome during high-grade serous ovarian cancer development [Hi-C]

Project description:Rewiring of master transcription factor cistrome during high-grade serous ovarian cancer development [Hi-C]

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Epigenomic remodeling of the PAX8 cistrome in high grade serous ovarian cancer

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-08-08 | E-GEOD-83101 | biostudies-arrayexpress

Epigenomic remodeling of the PAX8 cistrome in high grade serous ovarian cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-08-08 | GSE83101 | GEO

High-Grade Serous Ovarian Cancer-A Risk Factor Puzzle and Screening Fugitive.

Project description:High-grade serous ovarian cancer (HGSOC) is the most lethal tumor of the female genital tract. Despite extensive studies and the identification of some precursor lesions like serous tubal intraepithelial cancer (STIC) or the deviated mutational status of the patients (BRCA germinal mutation), the pathophysiology of HGSOC and the existence of particular risk factors is still a puzzle. Moreover, a lack of screening programs results in delayed diagnosis, which is accompanied by a secondary chemo-resistance of the tumor and usually results in a high recurrence rate after the primary therapy. Therefore, there is an urgent need to identify the substantial risk factors for both predisposed and low-risk populations of women, as well as to create an economically and clinically justified screening program. This paper reviews the classic and novel risk factors for HGSOC and methods of diagnosis and prediction, including serum biomarkers, the liquid biopsy of circulating tumor cells or circulating tumor DNA, epigenetic markers, exosomes, and genomic and proteomic biomarkers. The novel future complex approach to ovarian cancer diagnosis should be devised based on these findings, and the general outcome of such an approach is proposed and discussed in the paper.

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Epigenomic remodeling of the PAX8 cistrome in high grade serous ovarian cancer [ChIP-Seq]

2016-08-08 | E-GEOD-79893 | biostudies-arrayexpress

Epigenomic remodeling of the PAX8 cistrome in high grade serous ovarian cancer [RNA-Seq]

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