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Effect of chemical chaperone lumacaftor (VX-809) on gene expression in HEK-293 cells expressing hERG/A561V

ABSTRACT: To investigate the molecular effect of lumacaftor in the regulation of mutatant hERG protein expression, we established HEK-293 cell lines expressing hERG/A561V, 15μM lumacaftor treatment as experimental group (HAL) and DMSO treatment (HA) as control group. We then performed gene expression profiling analysis using data obtained from RNA-seq of 2 different groups.

ORGANISM(S): Homo sapiens

PROVIDER: GSE227304 | GEO | 2025/03/12

REPOSITORIES: GEO

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