PGE2 effect on unstimulated and exhausted human CD8+ T-cells

ABSTRACT: Prostaglandin E2 (PGE2) is overexpressed in many tumors and plays an important role in suppressing T-cell function. In this study, we investigated the effect of PGE2 in human T-cells. Importantly, PGE2 caused profound transcriptomic changes both in unstimulated and exhausted T-cells with many genes and pathways altered including T-cell lipid metabolism. Our study suggests that PGE2-induced metabolic reprogramming is detrimental to dysfunctional T-cells and TIL, and its manipulation could be used to dampen the immunosuppressive effects of PGE2.

ORGANISM(S): Homo sapiens

PROVIDER: GSE227316 | GEO | 2024/03/08

REPOSITORIES: GEO