Genomics

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Genome-wide mapping of NRF1 (NFE2L1) binding in HCT116 cells upon proteasome inhibition.


ABSTRACT: The maintenance of protein homeostasis is an essential characteristic of life. Transcription factor NRF1 (NFE2L1) has been reported to be activated by proteasome dysfunction, although the genome-wide target genes are poorly understood. Using ChIP-seq analysis, we found a potential association between NRF1 and autophagy. Our findings highlight the new activation mechanism of autophagy through gene regulation under proteasome dysfunction.

ORGANISM(S): Homo sapiens

PROVIDER: GSE227357 | GEO | 2023/03/19

REPOSITORIES: GEO

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