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RNA-seq profiling of in vitro activated naïve B cells reveals differences in B-cell activation and mismatch repair machinery in common variable immune deficiency (CVID)

ABSTRACT: To investigate the transcriptional dfferences during B-cell activation in healthy donors and patients with CVID we sorted naïve B cells from the two groups and activated with full BCR-engagement. We then performed differential expression analysis on the seuqneces and we also investigated what pathway changes that we could detect between healthy donors and CVID patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE227377 | GEO | 2023/04/05

REPOSITORIES: GEO

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