Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Brain transcriptomics reveal the activation of neuroinflammation pathways during acute Orientia tsutsugamushi infection in C57BL/6 mice

ABSTRACT: We performed RNAseq on total RNA extracted from brains of mice infected with Orientia tsutsugamushi to investigate the transcriptomic signature of this tissue throughout infection.

ORGANISM(S): Mus musculus

PROVIDER: GSE227525 | GEO | 2023/05/04

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Orientia tsutsugamushi

Project description:Orientia tsutsugamushi Raw Sequencing Reads

| PRJNA316643 | ENA

Alterations in Germinal Center Formation and B Cell Activation during Severe Orientia tsutsugamushi Infection in Mice [Nanostring]

Project description:We performed NanoString analysis on total RNA extracted from spleens of mice infected with Orientia tsutsugamushi to investigate the transcriptomic signature of these cells throughout infection.

2023-03-20 | GSE227523 | GEO

Alterations in Germinal Center Formation and B Cell Activation during Severe Orientia tsutsugamushi Infection in Mice

Project description:We performed RNAseq on total RNA extracted from splenic B cells isolated from mice infected with Orientia tsutsugamushi to investigate the dynamic transcriptomic signature of these cells throughout infection. We then performed differential expression analysis, meta-analysis, and gene set enrichment anaylsis using data obtained by RNA-seq of mock infected (D0) and O. tsutsugamushi-infected mice (D4 and D8).

2023-01-16 | GSE222692 | GEO

Orientia tsutsugamushi strain:Karp

Project description:Orientia tsutsugamushi strain:Karp Genome sequencing

| PRJNA813895 | ENA

Orientia tsutsugamushi, the agent of scrub typhus, induces an inflammatory program in human macrophages

Project description:Scrub typhus is a life-threatening disease caused by Orientia tsutsugamushi, a bacterium that mainly infects endothelial cells in vitro and in vivo. Evidence suggests that the interaction of O. tsutsugamushi with myeloid cells may play a pivotal role in O. tsutsugamushi infection. We showed here that O. tsutsugamushi intensively replicated within human monocyte-derived macrophages. Bacterial organisms stimulated the expression of a large panel of genes including type I interferon, interferon-stimulated, inflammatory, apoptosis-related genes and induced an M1-type gene response in macrophages. This transcriptional signature was accompanied by functional consequences such as the release of inflammatory cytokines such as Tumor Necrosis Factor and interleukin-gamma. Live O. tsutsugamushi organisms were necessary for type I interferon response and, to a lesser degree, to inflammatory response. As interferon-gamma is known to elicit M1 polarization, we assessed the effect of interferon-gamma on O. tsutsugamushi fate in macrophages. Exogenous interferon-gamma partly inhibited O. tsutsugamushi replication within macrophages. Our results suggest that the inflammatory response induced by O. tsutsugamushi may account for the local and systemic inflammation observed in scrub typhus and that interferon-gamma may be useful as an adjuvant treatment of patients with scrub typhus.

2013-01-29 | GSE38194 | GEO

Orientia tsutsugamushi, the agent of scrub typhus, induces an inflammatory program in human macrophages

2013-01-29 | E-GEOD-38194 | biostudies-arrayexpress

Brain transcriptomics reveal the activation of neuroinflammation pathways during acute Orientia tsutsugamushi infection in C57BL/6 mice

Project description:Brain transcriptomics reveal the activation of neuroinflammation pathways during acute Orientia tsutsugamushi infection in C57BL/6 mice

| PRJNA945452 | ENA

Orientia tsutsugamushi

Project description:Complete genomes of Orientia tsutsugamushi strains TW-1 and TW-22 in Taiwan

| PRJNA987430 | ENA

Orientia tsutsugamushi strain:AFSC4

Project description:Orientia tsutsugamushi strain:AFSC4 Genome sequencing and assembly

| PRJNA322207 | ENA

Orientia tsutsugamushi strain:Karp

Project description:Orientia tsutsugamushi strain:Karp Genome sequencing and assembly

| PRJNA322204 | ENA