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Impact of LCL161 on gene expression in human TAC T cells stimulated with antigen-coated microbeads

ABSTRACT: SMAC mimetics such as LCL161 are a novel class of anti-cancer drug that have been shown to induce costimulation in human T cells and augment anti-tumor capabilities. We investigated what impacts LCL161 has on gene expression in engineered anti-BCMA TAC T cells. TAC T cells were stimulated with BCMA-coated microbeads to deliver controlled antigenic signal alone.

ORGANISM(S): Homo sapiens

PROVIDER: GSE227986 | GEO | 2023/04/04

REPOSITORIES: GEO

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Impact of LCL161 on gene expression in human TAC T cells stimulated with antigen-coated microbeads

Project description:Impact of LCL161 on gene expression in human TAC T cells stimulated with antigen-coated microbeads

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