Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of FDX1 overexpression on gene expression in WSU-DLCL2 cells upon elesclomol stimulation

ABSTRACT: To investigate the function FDX1 in the regulation of elesclomol (ES)-induced cell death, we established WSU-DLCL2 cell lines in which the full-length coding sequence of FDX1 was overexpressed (FDX1-OE), we then performed gene expression profiling analysis using data obtained from RNA-seq of 2 different cells (control and FDX1-OE WSU-DLCL2) with or without elsclomol treatment

ORGANISM(S): Homo sapiens

PROVIDER: GSE228261 | GEO | 2023/03/30

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Effect of FDX1 overexpression on gene expression in SUDHL-4 cells upon elesclomol stimulation

Project description:To investigate the function FDX1 in the regulation of elesclomol (ES)-induced cell death, we established SUDHL-4 cell lines in which the full-length coding sequence of FDX1 was overexpressed (FDX1-OE), we then performed gene expression profiling analysis using data obtained from RNA-seq of 2 different cells (control and FDX1-OE SUDHL-4) with or without elsclomol treatment

2023-03-30 | GSE228263 | GEO

Effect of FDX1 overexpression on gene expression in WSU-DLCL2 cells upon elesclomol stimulation

Project description:Effect of FDX1 overexpression on gene expression in WSU-DLCL2 cells upon elesclomol stimulation

| PRJNA949166 | ENA

Effect of FDX1 overexpression on gene expression in SUDHL-4 cells upon elesclomol stimulation

Project description:Effect of FDX1 overexpression on gene expression in SUDHL-4 cells upon elesclomol stimulation

| PRJNA949165 | ENA

Hs 294T Cells Treated with Elesclomol Alone or in Combination with NAC Compared to DMSO Treated

2008-05-29 | GSE11551 | GEO

Hs 294T Cells Treated with Elesclomol Alone or in Combination with Paclitaxel Compared to DMSO Treated

2008-05-29 | GSE11550 | GEO

Transcription profiling of human Hs 294T cells treated with elesclomol alone or in combination with paclitaxel compared to DMSO treated

Project description:We used microarrays to detail gene expression changes in Hs 294T human melanoma cells after treatment with elesclomol alone, or in combination with paclitaxel, to aide in identifing the mechnism of action of elesclomol. Experiment Overall Design: Hs 294T human melanoma cells were grown in vitro. They were seeded at a low density and were left untreated, treated with the vehicle, treated with elesclomol, treated with paclitaxel, or treated in combination with both elesclomol and paclitaxel. They were incubated for 6 hours before harvesting.

2008-06-19 | E-GEOD-11550 | biostudies-arrayexpress

Transcription profiling of human 294T Cells treated with elesclomol alone or in combination with NAC compared to DMSO treated

Project description:We used microarrays to detail gene expression changes in Hs 294T human melanoma cells after treatment with elesclomol alone, or in combination with NAC, to aide in identifing the mechnism of action of elesclomol. Experiment Overall Design: Hs 294T human melanoma cells were grown in vitro. They were seeded at a low density and were left untreated, treated with the vehicle, treated with elesclomol, treated with NAC, or treated in combination with both elesclomol and NAC. The cells treated with NAC were given the NAC 30 minutes prior to additional treatments. They were incubated for 6 hours before harvesting.

2008-06-18 | E-GEOD-11551 | biostudies-arrayexpress

Transcription profiling of human 294T cells treated with elesclomol in combination with paclitaxel or NAC

Project description:This SuperSeries is composed of the following subset Series:; GSE11550: Hs 294T Cells Treated with Elesclomol Alone or in Combination with Paclitaxel Compared to DMSO Treated; GSE11551: Hs 294T Cells Treated with Elesclomol Alone or in Combination with NAC Compared to DMSO Treated Experiment Overall Design: Refer to individual Series

2008-06-19 | E-GEOD-11552 | biostudies-arrayexpress

Effect of overexpression of FNDC5 on gene expression upon hypoxia 24 h of bone marrow-mesenchymal stem cells (BMSCs).

Project description:To investigate the function of FNDC5 in the regulation of autophagy, we established BMSCs-OE-FNDC5 in which the target gene FNDC5 has been overexpressed by lentivirus transfection.

2023-09-13 | GSE231837 | GEO

CENP-A overexpression promotes aneuploidy and karyotypic heterogeneity

Project description:Centromeric localization of the evolutionarily conserved histone H3 variant, CENP-A. is essential for chromosomal stability. CENP-A overexpression (OE) causesd its mislocalization to non-centromeric regions resulting in chromosomal instability (CIN) in yeast, flies and human cells. CENP-A OE and mislocalization have been observed in cancers and correlates with poor prognosis. However, the molecular consequences of CENP-A OE on CIN and aneuploidy have not been defined. Here, we overexpressed YFP-CENP-A in a pseudodiploid DLD1 cell line and showed that CENP-A OE leads to its mislocalization and CIN due to defects in kinetochore integrity and kinetochore-microtubule attachments. CENP-A OE also leads to its mislocalization and CIN in a xenograft mouse model. Under these conditions, it contributes to aneuploidy with karyotypic heterogeneity in human cells and xenograft mouse model. In summary, our studies provide a molecular link between CENP-A OE and aneuploidy, and suggest that karyotypic heterogeneity may contribute to the aggressive phenotype of CENP-A overexpressing cancers.

2020-07-16 | GSE154460 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data