Bulk RNA-sequencing of articular cartilage from DMM-treated mice

ABSTRACT: Identify the therapeutic targets/pathways of Osteoarthritis (OA), the most frequent joint disease. Surgery-induced cartilage degeneration is used as an experimental model for OA in mice. An inducible cartilage-specific c-Fos loss-of-function model is generated by combining c-fos floxed and Col2a1-CreERT mice. Since c-Fos mutant mice have more severe phenotype than c-Fos wild type mice, we focused on c-Fos-related signaling pathway in the articular cartilage.

ORGANISM(S): Mus musculus

PROVIDER: GSE228469 | GEO | 2023/06/01

REPOSITORIES: GEO