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Effect of BAF disruption on T-bet binding in activated CD8+ T cells [ChIP-seq]

ABSTRACT: To investigate the role of cBAF in regulation of Tbet binding, polyclonal naive CD8 T cells were stimulated for 48h with anti-CD3, CD28, and hIL-2. Cells were then treated with DMSO, ACBI1, or BRM014 for 6 hours, and treated with recombinant mouse IL-12 for the last two hours of inhibitor treatment. ChIP-seq against T-bet was then performed.

ORGANISM(S): Mus musculus

PROVIDER: GSE228546 | GEO | 2023/06/13

REPOSITORIES: GEO

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