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Expression data from transgenic mice with conditional deletion of CDKN2A/p16 in esophageal glandular cells

ABSTRACT: The tumor suppressor CDKN2A Exon 1a (coding for p16) was removed in esophageal and squmous-columnar junction (SCJ) epithelial cells when tamoxifen was injected in experimental mice. Sections of the SCJ were subjected to laser capture microdissection to retain only the glandular mucosal layer. RNA was extracted and analyzed by Affymetrix Clariom D Pico assay, mouse (Thermo Fisher, Waltham, MA). We used microarrays to identify transcriptomic changes associated with p16 knockout.

ORGANISM(S): Mus musculus

PROVIDER: GSE228618 | GEO | 2025/03/01

REPOSITORIES: GEO

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