Promotion of TLR7-MyD88-dependent Inflammation and Autoimmunity through Stem-loop Changes in Lnc-Atg16l1
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ABSTRACT: In this study, we employed a combination of Endosome RNA-seq and iCLIP-seq technologies to identify long non-coding RNA associated with TLR7 and Myd88 in mouse HA-mTLR7 stable overexpression and wild type RAW264.7 cells. RNA-seqs of wild type and Lnc-Atg16l1 RAW264.7 cells were applied to function study. We performed icSHAPE-seq to investigate RNA secondary structure of Lnc-Atg16l1 in RAW264.7 cells with or without stumulatied by R837, as well as in spleen cells from BXSB.Yaa and BXSB.B6 mice.
ORGANISM(S): Mus musculus
PROVIDER: GSE228970 | GEO | 2024/10/12
REPOSITORIES: GEO
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