Transcriptomics

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UBR7 an E3 ligase targets Sp110 via modulating IFN beta signalling in HBV-induced hepatic carcinoma


ABSTRACT: UBR7 is an E3 ubiquitin ligase. We identified that Sp110 is a novel substrate for UBR7 which promotes HBV persistence. UBR7 ubiquitinates Sp110 which leads to downregulation of type I interferon response pathway genes. Our study reports that UBR7 ubiquitinates Sp110 thereby promoting viral persistence and HBV- induced HCC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE229339 | GEO | 2023/12/31

REPOSITORIES: GEO

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