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Circular RNA research in AML

ABSTRACT: To investigate the effects of circRNA in AML, we collected the PBMC of AML patients and healthy volunteers and performed high-throughput sequencing, the results showed that circRNA_01 was differentially expressed in AML and normal samples. This suggests that circRNA_01 might play an important role in regulating AML. In order to find out the cohort of genes whose expression was regulated by circRNA_01, we constructed THP-1/U937 cell lines stably infected with lentiviral particles carrying control shRNA (sh_NC) or circRNA_01 shRNA. Subsequently, total RNA was isolated and then performed transcriptome RNA sequence

ORGANISM(S): Homo sapiens

PROVIDER: GSE229582 | GEO | 2025/02/08

REPOSITORIES: GEO

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