Other

Dataset Information

0

Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations [bulk DNA-Seq]

ABSTRACT: Available genetically-defined cancer models are limited in genotypic and phenotypic complexity and underrepresent the heterogeneity of human cancer. Herein, we describe a combinatorial genetic strategy applied to an organoid transformation assay to rapidly generate diverse, clinically relevant models of bladder and prostate cancer. Importantly, the clonal architecture of the resultant tumors can be resolved using single-cell or spatially resolved next-generation sequencing to uncover polygenic drivers of cancer phenotypes.

ORGANISM(S): Mus musculus

PROVIDER: GSE229781 | GEO | 2023/12/01

REPOSITORIES: GEO

Json Xml

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

Other Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations [scDNA-seq_MOI]
2023-12-01 | GSE231543 | GEO
Other Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations [DNA-seq_distribution]
2023-12-01 | GSE231542 | GEO
Transcriptomics Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations [RNA-Seq]
2023-12-01 | GSE229780 | GEO
Other Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations [scDNA-Seq]
2023-12-01 | GSE229782 | GEO
Transcriptomics Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations
2023-12-01 | GSE229783 | GEO
Genomics Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations
| PRJNA955814 | ENA
Genomics Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations [scDNA-Seq]
| PRJNA955821 | ENA
Genomics Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations [RNA-Seq]
| PRJNA955816 | ENA
Genomics Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations [scDNA-seq_MOI]
| PRJNA966761 | ENA
Genomics Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations [DNA-seq_distribution]
| PRJNA966760 | ENA