Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The transcriptional role of TG2-mediated H3Q5ser in CRC [RNA-seq]

ABSTRACT: We investigated the alteration of H3Q5ser upon RNF40-depleted or TG2-depleted HCT116 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE229844 | GEO | 2025/04/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

The transcriptional role of TG2-mediated H3Q5ser in CRC [ChIP-seq]

Project description:We investigated the alteration of H2Bub1, H3K4me3, and H3Q5ser upon RNF40-depleted or TG2-depleted HCT116 cells.

2025-04-01 | GSE229843 | GEO

The transcriptional role of TG2-mediated H3Q5ser in CRC

Project description:The transcriptional role of TG2-mediated H3Q5ser in CRC

| PRJNA956434 | ENA

The transcriptional role of TG2-mediated H3Q5ser in CRC [RNA-seq]

Project description:The transcriptional role of TG2-mediated H3Q5ser in CRC [RNA-seq]

| PRJNA956440 | ENA

The transcriptional role of TG2-mediated H3Q5ser in CRC [ChIP-seq]

Project description:The transcriptional role of TG2-mediated H3Q5ser in CRC [ChIP-seq]

| PRJNA956437 | ENA

Transcriptomic analysis of mouse splenic B cells that are either TG2-sufficient or TG2-deficient

Project description:To compare the transcriptomes of TG2-sufficient and TG2-deficient mouse splenic B cells under resting and stimulated conditions.

2019-11-08 | E-MTAB-7567 | biostudies-arrayexpress

The transcriptional role of TG2-mediated H3Q5ser in CRC

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-04-01 | GSE229845 | GEO

Gene expression profiling of ATRA-differentiated wild-type and TG2 knockout NB4 cells

Project description:Treatment of acute promyelocytic leukemia (APL) with all-trans-retinoic acid (ATRA) results in terminal differentiation of leukemic cells toward neutrophil granulocytes. Administration of ATRA leads to massive changes in gene expression, including down-regulation of cell proliferation-related genes and induction of genes involved in immune function. One of the most induced genes in APL NB4 cells is transglutaminase 2 (TG2). RNAi-mediated stable silencing of TG2 in NB4 cells (TG2-KD NB4) coupled with whole genome microarray analysis revealed that TG2 is involved in the expression of a large number of ATRA-regulated genes. The affected genes participate in granulocyte functions and their silencing lead to reduced adhesive, migratory and phagocytic capacity of neutrophils and less superoxide production. The expression of genes related to cell cycle control also changed, suggesting that TG2 regulates myeloid cell differentiation. CC chemokines CCL2, 3, 22, 24 and cytokines IL1B and IL8 involved in the development of differentiation syndrome (DS) are expressed at significantly lower levels in TG2-KD NB4 cells than in wild-type NB4 cells upon ATRA treatment. Based on our results, we propose that reduced expression of TG2 in differentiating APL cells may suppress effector functions of neutrophil granulocytes and attenuate the ATRA-induced inflammatory phenotype of DS. We used microarrays to detail the global program of gene expression underlying ATRA-induced differentiation of TG2 knockout NB4 cells. TG2 knockout NB4 cells were differentiated for 48 and 72 hours in the presence of ATRA and their gene expression profiles were compared to the wild-type cells at the same time points. Undifferentiated wild-type and TG2 knockout NB4 cells were used as untreated controls. Three biological replicates each.

2010-12-01 | E-GEOD-23702 | biostudies-arrayexpress

Acerihabitans sp. TG2

Project description:Acerihabitans sp. TG2 Genome sequencing and assembly

| PRJNA1041642 | ENA

Gene expression profiling of ATRA-differentiated wild-type and TG2 knockout NB4 cells

2010-12-01 | GSE23702 | GEO

Next Generation Sequencing of Ovarian Cancer Cells upon Exposure to Ascites from Wild Type and TG2-/- Mice

Project description:The goal of this study was to compare signaling pathways in ovarian cancer cells exposed in vitro or in vivo to peritoneal tumor microenvironment of host TG2+/+ vs. TG2-/- mice. For this, we performed NGS-derived transcriptome profiling (RNA-seq) followed by Ingenuity Pathway Analysis (IPA) of ID8 ovarian cancer cells.

2021-10-06 | GSE139686 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data