Transcriptomics

Dataset Information

0

Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway


ABSTRACT: Global warming and rising temperature significantly increase the incidence of heat stress, which is known to affect the process of inflammation and aging. However, the effect of heat stress on skin melanogenesis is not fully known. We found that healthy foreskin tissues underwent significant pigmentation when exposed to 41℃. Furthermore, heat stress promoted melanogenesis in pigment cells by increasing the paracrine effects of keratinocytes. High-throughput RNA sequencing showed that heat stress activates the Hedgehog (Hh) signaling pathway in keratinocytes. The agonists of Hh signaling promote the paracrine effect of keratinocytes on melanogenesis. In addition, TRPV3 agonists activate the Hh signaling in keratinocytes and augment its paracrine effect on melanogenesis. The heat-induced activation of Hh signaling is dependent on TRPV3-mediated Ca2+ influx. Heat exposure promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway. Our findings provide insights into the mechanisms of heat-induced skin pigmentation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE229915 | GEO | 2023/05/20

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA956578 | ENA
2018-01-03 | GSE107450 | GEO
2014-02-03 | E-GEOD-54359 | biostudies-arrayexpress
2013-12-24 | E-GEOD-53615 | biostudies-arrayexpress
2013-12-24 | E-GEOD-53614 | biostudies-arrayexpress
2023-07-24 | PXD042762 | Pride
2010-11-03 | E-GEOD-24028 | biostudies-arrayexpress
2010-11-03 | E-GEOD-23999 | biostudies-arrayexpress
2010-11-03 | E-GEOD-24024 | biostudies-arrayexpress
2023-09-11 | GSE239634 | GEO