Microarray analysis of human neuroblastoma cells exposed to aluminum, B-amyloid or the B-amyloid aluminum complex
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ABSTRACT: A typical pathological feature of Alzheimer’s disease (AD) is the appearance in the brain of senile plaques made up of B-amyloid (AB) and neurofibrillary tangles. Ad is also associated with an abnormal accumulation of some metal ions and we have recently shown that one of these, aluminum (Al), plays a relevant role in affecting AB aggregation and neurotoxicity. In this study, employing a microarray analysis of 29,166 genes, we investigated the effects induced by the exposure to the AB-Al complex on the gene expression profile of a cell line of neuronal-like cells, the SH-SY5Y. Results from the microarray essay indicate that, compared to AB or Al alone, exposure to AB-Al produced selective changes in gene expression. Some of the genes selectively over or under expressed are directly related to AD.
ORGANISM(S): Homo sapiens
PROVIDER: GSE23000 | GEO | 2011/02/10
SECONDARY ACCESSION(S): PRJNA127843
REPOSITORIES: GEO
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