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Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis [RNA-seq_PBMC]

ABSTRACT: we present a novel path to drug repurposing to identify new immunotherapies for ASCVD. The integration of time of-flight mass cytometry (CyTOF) and RNA-sequencing identified unique inflammatory signatures in peripheral blood mononuclear cells (PBMCs) stimulated with ASCVD plasma. By comparing these inflammatory signatures to large-scale gene expression data from the LINCS L1000 dataset, we identified drugs that could reverse this inflammatory response. In conclusion, a systems immunology-driven drug repurposing with pre- clinical validation strategy can aid the development of new cardiovascular immunotherapies.

ORGANISM(S): Homo sapiens

PROVIDER: GSE230214 | GEO | 2023/04/23

REPOSITORIES: GEO

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