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Dose dependent reprogramming of neutrophils by LPS

ABSTRACT: We have performed analyses of murine primary bone marrow derived neutrophils challenged with either ultra-low dose or high dose of LPS. Neutrophils can be differentially programmed to distinct states by varying dosages of LPS. Purified bone marrow neutrophils were treated with PBS, 100 pg/ml LPS or 100 ng/ml LPS overnight, and harvested for scRNAseq analysis to examine their profiles of gene expression.

ORGANISM(S): Mus musculus

PROVIDER: GSE230241 | GEO | 2023/12/27

REPOSITORIES: GEO

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