Transcriptomics

Dataset Information

0

Immunoprofiling of mouse prostate cancer infiltrate


ABSTRACT: NK cells are effector cells that contribute to tumor immune surveillance. Due to their spontaneous ability to eliminate tumor cells, NK cell have been exploited for cancer treatment. However, most cancers impair NK cell infiltration and hinder their cytotoxic capability. As a consequence, the efficacy of NK cell-based immunotherapies is still limited. Here we applied high dimensional single-cell RNA-seq to profile the transcriptional landscape of tumor-infiltrating NK in murine prostate cancer. We identified two subsets of tumor infiltrating NK cells. Tumor samples resulted to be abundantly infiltrated by the immunomodulatory subset at the expense of the cytotoxic one. Importantly, the anayles of the interaction network existing between NK cells and tumor cells revealed a deregulation of the autophagic process. Finally, genetic and pharmacological activation of autophagy rescues NK cell effector functions and confers to NK cells a superior ability in controlling tumor growth in vivo.

ORGANISM(S): Mus musculus

PROVIDER: GSE230311 | GEO | 2024/10/09

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-01-12 | GSE153892 | GEO
2024-01-31 | GSE253993 | GEO
2020-03-20 | MODEL2003040001 | BioModels
2023-07-18 | E-MTAB-13157 | biostudies-arrayexpress
2020-04-03 | PXD014894 | Pride
2021-09-10 | GSE156199 | GEO
2021-09-10 | GSE143375 | GEO
2020-11-02 | E-MTAB-8777 | biostudies-arrayexpress
2024-08-12 | MSV000095572 | MassIVE
2021-09-09 | PXD018982 | Pride