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Apelin 13 breaks the immune cell route from lung to brain [scRNA-Seq]

ABSTRACT: To investigate the effect of Apelin 13 on lung in experimental autoimmune encephalomyelitis(EAE) at peak, we perform single cell RNA sequencing of the whole lung of Control, EAECont and EAE with Apelin 13 treatment(EAEA13)

ORGANISM(S): Mus musculus

PROVIDER: GSE230550 | GEO | 2024/06/14

REPOSITORIES: GEO

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Apelin 13 breaks the immune cell route from lung to brain [RNA-Seq]

Project description:We treated HUVEC with Apelin 13 or siRNA of Aplnr to investigate the impact of Apelin 13 and APLNR knockdown. We then performed gene expression profiling analysis using data obtained from RNA-seq of 7 different conditions.

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Apelin 13 breaks the immune cell route from lung to brain

Project description:Apelin 13 breaks the immune cell route from lung to brain

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Apelin 13 breaks the immune cell route from lung to brain [RNA-Seq]

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Apelin 13 breaks the immune cell route from lung to brain [scRNA-Seq]

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Apelin/APJ signaling mediated by G alpha 13 and MEF2 in endothelial cells

Project description:Evaluation of gene transcripts that are downstream of apelin/APJ signaling in HUVECs Duplicates per group, subjected to: 1) control siRNA, 2) MEF2A and MEF2C siRNA, 3) G alpha 13 siRNA, and 4) apelin and APJ siRNA

2013-05-11 | E-GEOD-46825 | biostudies-arrayexpress

Apelin 13 breaks the immune cell route from lung to brain

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-06-14 | GSE230551 | GEO

Apelin-13 modulates the endometrial transcriptome of the domestic pig during the implantation phase of pregnancy

Project description:Apelin is a hormone secreted primarily by white adipose tissue. Recent studies have shown that adipokine and its receptor, APJ, are expressed in different reproductive tissues, including the ovary and uterus, which suggests that it may act as an important local regulator of reproductive functions. This study aimed to explore the influence of apelin on global gene expression in the porcine endometrium during early gestation, on days 15 to 16 of pregnancy (implantation period). We analysed samples obtained from 4 individuals (n=4). The tissue explants obtained from the uterine horns were divided into controls [without treatment] and apelin-13 (20 ng/mL) treated ones. In vitro tissue cultures were conducted for 24 hours.

2024-03-18 | E-MTAB-13773 | biostudies-arrayexpress

Apelin/APJ signaling mediated by G alpha 13 and MEF2 in endothelial cells

Project description:Evaluation of gene transcripts that are downstream of apelin/APJ signaling in HUVECs

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Quantitative proteome profiling of CNS-infiltrating autoreactive CD4+ cells reveals selective changes during experimental autoimmune encephalomyelitis

Project description:Experimental autoimmune encephalomyelitis (EAE) is a murine model of multiple sclerosis, a chronic neurodegenerative and inflammatory autoimmune condition of the central nervous system (CNS). Pathology is driven by the infiltration of autoreactive CD4+ lymphocytes into the CNS where they attack neuronal sheaths causing ascending paralysis. We used an isotope-coded protein labelling approach to investigate the proteome of CD4+ cells isolated from the spinal cord and brain of mice at various stages of EAE progression in two EAE disease models; PLP139-151-induced relapsing-remitting EAE and MOG35-55-induced chronic EAE, which emulate the two forms of human multiple sclerosis. A total of 1120 proteins were quantified across disease onset, peak-disease and remission phases of disease and of these, 13 up-regulated proteins of interest were identified with functions relating to the regulation of inflammation, leukocyte adhesion and migration, tissue repair and the regulation of transcription/translation. Proteins implicated in processes such as inflammation (S100A4 and S100A9) and tissue repair (Annexin A1), which represent key events during EAE progression were validated by quantitative PCR. This is the first targeted analysis of autoreactive cells purified from the CNS during EAE, highlighting fundamental CD4+ cell-driven processes that occur during the initiation of relapse and remission stages of disease.

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Apelin absence in endothelial cells

Project description:First, transcriptome analysis of purified CD31+ endothelial cells (ECs) from VEGF-treated sprouting embryoid bodies showed angiogenesis as the top affected category when Apelin is not present. In addition, loss of Apelin resulted in the modulation of pathways in ECs related to vasculogenesis, cell adhesion and response to hypoxia. Ingenuity Pathway Analysis (IPA) further identified VEGFR pathway as the main upstream regulator affected in endothelial cells, closely followed by the TGFβ1 and TNF pathways, all reduced in the absence of Apelin. The most inhibited genes from the VEGFR pathway in the absence of Apelin are angiogenesis-related genes. Second, transcriptome analysis of CD31+/CD105+ ECs sorted from Apelin wild-type and Apln-depleted tumors found a significant decrease in processes associated with endothelial cell proliferation and angiogenesis in ECs sorted out of Apelin-depleted tumors using IPA. Further, IPA predicted a decrease in the adhesion of granulocytes and upstream regulator analysis showed that proteins of the TGF-superfamily, Inhibin-βA and TGF-β1, as well as C/EBP-alpha, β-Catenin, ErbB2 and EGFR are predicted to be inhibited upstream regulators in ECs isolated from Apelin-depleted tumors.

2019-05-27 | GSE100293 | GEO

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